Open postdoctoral position in Alternative Splicing in Pancreatic Cancer Metastasis at the Moffitt Cancer Center’s Molecular Oncology Department.
Project Information
The goal of the Mann lab is to identify new mechanisms behind the progression and recurrence of pancreatic adenocarcinoma (PDAC). The process of alternative splicing is essential to the development of cancer, and mechanisms that regulate splicing as the illness progresses represent an intriguing and rapidly developing field of research in PDAC biology. It has been demonstrated lately that PDAC metastasis is facilitated by the downregulation of the RNA binding protein RBFOX2, which leads to alternative splicing that strengthens cytoskeletal remodelling programmes that encourage cell invasion and migration. The processes by which RBFOX2-mediated splicing events augment the carcinogenic potential of proteins to advance PDAC are presently being investigated. To join their team and help us achieve our objective of identifying splicing regulators and specific splicing events in PDAC progression and relapse disease that may be investigated for diagnostic or therapeutic efficacy to better treat cancer patients, they are seeking a post-doctoral fellow who is enthusiastic about inter-disciplinary science.
Qualifications
PhD in Genetics, Molecular Biology, Biochemistry or related discipline earned within the last two years.
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Requirements
- Has a strong foundation in molecular biology and cancer biology,
- Has knowledge of mammalian cell culture, including both 2D and 3D cultures, and is skilled at carrying out phenotypic tests (such as colony formation, invasion, and migration),
- It is extremely desirable to have prior experience with pancreatic cancer or alternative splicing,
- Knowledge of NGS and mouse genetics is beneficial but not necessary.
Deadline and Application
Deadline Not Available. For more details and application visit the official website.
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